Revista da Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo

Online first

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo - Online first: 2018-06-20
Original article

Giant adrenal adenoma presenting as Cushing syndrome

Monteiro AM


We present a case of a 37-years-old male with progressive facial flushing, hair growth in dorsal and lumbar back, easy bruising and diminished libido. The laboratorial workup revealed an ACTH-independent Cushing syndrome and elevated levels of testosterone, dehydroepiandrosterone sulfate and androstenedione. CT scan demonstrated a 10 cm, regular and well-defined lesion in the right adrenal with a heterogeneous pattern of density. The patient was submitted to a right adrenalectomy and the histological exam described a benign lesion without any Weiss criteria. This case represented a clinical challenge due to the overlapping of biochemical and imaging characteristics that prevented a final pre-surgical diagnosis. As histologic criteria can be misleading, long-term follow-up is advisable. So far, the patient is asymptomatic without clinical evidence of hypercortisolism and/or hyperandrogenism.

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