Health-Related Physical Fitness in Women with Dunnigan Lipodystrophy with Mutation in LMNA Gene
Introduction: The objective of this study was to compare health-related physical fitness in women with familial partial lipodystrophy type 2 (FPLD2) with healthy without FPLD2 control subjects.
Methods: We selected 14 patients with clinical signs and symptoms of FPLD2 and with mutation of LMNA gene and 14 control patients, who were evaluated for anthropometric variables and body composition by dual-energy X-ray absorptiometry and physical fitness (cardiopulmonary, flexibility, grip strength and abdominal muscular strength). There were no differences in weight, height or body mass index.
Results: Of the 14 women with FPLD2, nine (64.3%) reported type 2 diabetes mellitus and hypertension, and 13 (92.8%) hypertriglyceridemia. Regarding physical fitness, women with FPLD2 presented decreased in the amplitude of the ankle joint (p < 0.04), and reduced abdominal muscle resistance (p < 0.012), heart rate (p = 0.032) and peak effort power (p = 0.045). Laboratory tests showed that women with FPLD2 had increased levels of uric acid, glycemia, HbA1c, insulin, triglycerides, CRP, ALT and AST and reduced levels of HDL-c (p < 0.017) compared to CG.
Conclusion: The women with LPFD2 showed physical fitness levels decreased when compared to the control group. Future studies are needed to investigate the physical activity and to encourage preventive measures in this population.
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