Health-Related Physical Fitness in Women with Dunnigan Lipodystrophy with Mutation in LMNA Gene

  • Luciana Monteiro Division of Endocrinology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Maria Cristina Foss-Freitas Division of Endocrinology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Júlio Crescêncio Laboratory of Exercise Physiology - Division of Cardiology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Lourenço Gallo Júnior Laboratory of Exercise Physiology - Division of Cardiology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Fernanda Coelis Division of Endocrinology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Francisco Pereira Division of Endocrinology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
  • Estela Carneseca Institute of Education and Research, Foundation Institution Pio XII - Cancer Hospital of Barretos, Barretos, Brazil
  • Renan Montenegro Júnior Department of Community Health, Service of Endocrinology and Diabetes, University Hospital Walter Cantídio, Fortaleza Medical School, Ceará University, Fortaleza, Brazil
  • Milton Foss Division of Endocrinology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

Abstract

 Introduction: The objective of this study was to compare health-related physical fitness in women with familial partial lipodystrophy type 2 (FPLD2) with healthy without FPLD2 control subjects. 


Methods: We selected 14 patients with clinical signs and symptoms of FPLD2 and with mutation of LMNA gene and 14 control patients, who were evaluated for anthropometric variables and body composition by dual-energy X-ray absorptiometry and physical fitness (cardiopulmonary, flexibility, grip strength and abdominal muscular strength). There were no differences in weight, height or body mass index. 


Results: Of the 14 women with FPLD2, nine (64.3%) reported type 2 diabetes mellitus and hypertension, and 13 (92.8%) hypertriglyceridemia. Regarding physical fitness, women with FPLD2 presented decreased in the amplitude of the ankle joint (p < 0.04), and reduced abdominal muscle resistance (p < 0.012), heart rate (p = 0.032) and peak effort power (p = 0.045). Laboratory tests showed that women with FPLD2 had increased levels of uric acid, glycemia, HbA1c, insulin, triglycerides, CRP, ALT and AST and reduced levels of HDL-c (p < 0.017) compared to CG. 


Conclusion: The women with LPFD2 showed physical fitness levels decreased when compared to the control group. Future studies are needed to investigate the physical activity and to encourage preventive measures in this population. 

Published
Jul 6, 2017
How to Cite
MONTEIRO, Luciana et al. Health-Related Physical Fitness in Women with Dunnigan Lipodystrophy with Mutation in LMNA Gene. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, [S.l.], v. 12, n. 1, p. 22-28, july 2017. ISSN 2183-9514. Available at: <http://www.spedmjournal.com/index.php/spedm/article/view/77>. Date accessed: 18 nov. 2017.
Section
Original Articles